Lymphocyte-Depleted Thymic Remnants

Lymphocyte-depleted thymic remnants: a potential diagnostic pitfall in the evaluation of central neck dissections.

The head and neck region is a frequent site for potentially confusing incidental benign findings not related to the primary pathologic process and having no impact on patient prognosis. Several lesions are thymic in origin. We report 3 cases of lymphocyte-poor thymic remnants identified in central cervical (level VI) lymph node dissections for unrelated benign and malignant pathology. In each, ...

Thymic changes in the magnesium-depleted rat.

SUMMARY The effects of a magnesium-deficient diet fed to rats for approximately 65 days have been assessed with special reference to changes in the thymus. The thymus was enlarged in 18 to 52% of deficient animals surviving more than 6 to 7 weeks in various experiments. The remainder demonstrated glands that were smaller than controls. The enlarged thymuses showed marked cellular changes with t...

Post-thymic T lymphocyte maturation during ontogenesis

Peripheral T lymphocytes from newborn (4-6-d-old) mice, isolated from the spleen or lymph nodes, show phenotypic features of immature cortical thymocytes, such as high frequencies of proliferating cells and of peanut lectin-binding cells. These are features of peripheral T cells of recent thymic origin, as shown by in situ labeling of thymocytes and subsequent observation of the migrants to the...

Growth of mycobacterium bovis (BCG) in T lymphocyte-depleted mice.

BCG Montreal (10-6 viable bacilli) injected intravenously into adult thymectomized, irradiated, and bone marrow-reconstituted (THXB) C57Bl times C3H F1 hybrid mice induced a progressive systemic infection which killed 95% of the animals within 60 days. Control mice infected with this dose of BCG did not die. The infected THXB mice failed to develop detectable levels of tuberculin hypersensitivi...

Lymphocyte Progenitor Cells Causes Thymic Cell Proliferation Arrest within Intrathymic